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KMID : 0357919860200030305
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Korean Journal of Pathology
1986 Volume.20 No. 3 p.305 ~ p.312
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Morphological Changes of Coronary Arteries in Childhood
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Abstract
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The coronary arteries of young individuals are histologically studied. Fourteen cases in
pediatric age group and three adult hearts were used. No case had clinical and
pathological evidences of heart disease.
Inner circumference, thickness of tunicae intima, media and adventitia were measured
at eight different sites of coronary arteries. The thickness of tunica media was used as
a standard scale of cardiac growth, and the heart weight, body weight, height and age
were compared with the medial thickness.
The morphological changes were assessed in five groups by the heart weights. Group
I (less than 10 gm) showed single endothelial lining with cytoplasmic vacuolization or
endothelial denudation. Group Ⅱ(more than 10 but less than 20 gm) consisted of full
term babies and showed first stigma of focal intimal thickening and intimal collagen
fibers.
Diffuse intimal thickening more than 1/1 of medial thickness was first seen in a case
with 46 gm of heart weight. Elastic fiber was not seen in internal elastic laminae of
groups I and Ⅱ.
Fragmentation of interval elastic lamina and smooth muscle proliferation as a form of
musculoelastic layer were the major findings of intimal thickening in childhood and no
case showed complicated atherosclerotic lesions.
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